(⁴³Ca) Calcium NMR

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ü ^43Ca

ü Properties of ^43Ca

Safety note: Some of the materials mentioned here are very dangerous. Ask a qualified chemist for advice before handling them. Qualified chemists should check the relevant safety literature before handling or giving advice about unfamiliar substances. NMR solvents are toxic and most are flammable. Specifically, calcium salts are non-toxic on account of their calcium under normal circumstances, however, their anions may be toxic.

⁴³Calcium NMR

⁴³Calcium (⁴³Ca) is a moderately sensitivity nucleus but with a very low natural abundance that yields moderately sharp lines in symmetric environments over a small chemical shift range. ⁴³Ca is a spin 7/2 nucleus and is therefore quadrupolar. As a result, the signal width increases with asymmetry of the environment. ⁴³Ca NMR is mostly used in relaxation studies to determine binding to DNA, proteins, etc. Because of its extremely low sensitivity at natural abundance, it is usually isotopically enriched for these studies despite the cost. There is little information available about chemical shifts.

Chemical shift ranges for calcium NMR

⁴³Ca-NMR spectrum of CaCl₂ (1M) in D₂O

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Properties of ⁴³Ca

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Spin	7/2
Natural abundance	0.135%
Chemical shift range	70 ppm, from -35 to 35
Frequency ratio (Ξ)	6.730029%
Reference compound	0.1 M CaCl2 in D2O
Linewidth of reference	0.5 Hz
T1 of reference	1 s
Receptivity rel. to ^1H at natural abundance	8.68 × 10^-6
Receptivity rel. to ^1H when enriched	6.42 × 10^-3
Receptivity rel. to ^13C at natural abundance	0.0510
Receptivity rel. to ^13C when enriched	37.8
Linewidth parameter	2.3 fm^4

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Updated 2006-10-03 © Roy Hoffman, Hebrew University 1996-2006