| |
|
| |
|
|
| |
|
|
 |
|
Bioinorganic Chemistry: On the
Interface of Coordination Chemistry and Biology |
| |
|
|
Design of novel chelating ligands for transition metal
complexes
Design of inorganic compounds with biological and medicinal
applications;
Study of their reactivity and mechanism of action
Development of synthetic model compounds of metalloproteins having
variable chemical and medicinal applications
Development of small molecule and polymer bound metal compounds and
study of their potential therapeutic value |
|
| |
| |
Ti(IV) Complexes for Biological
Applications |
 |
| |
|
| |
In this project we synthesize Ti(IV) complexes of various
ligands
and study their properties and reactivity with emphasis on elucidating
their hydrolytic behavior. We have developed several compounds
exhibiting varying degrees of cytotoxicity, with interesting effects of
steric bulk and particular ligand type, and obvious correlation to
their hydrolytic behavior. We are currently focusing on elucidating the
nature of the active species and elucidating various mechanistic
aspects of the cytotoxic activity. |
|
| |
 |
|
Copper(I) Complexes as models for
metallochaperones active site |
| |
|
| |
In this project we synthesize complexes of copper(I) with
thiolato ligands
to model the binding site in copper metallochaperone proteins. In the
natural systems, copper binding is achieved through two cysteine
residues. We employ simple thiolato ligands as well as peptides
featuring a similar sequence to that of the natural system. We study
various aspects of their properties and reactivity, including binding
modes, redox potential, interaction with biologically relevant
oxygen-based species, etc.
|
|
|
|
| |
|
 |
|
