(46) Reingewertz, T.H., Deborah E. Shalev, D.E., Sukenik, S.,Ofrah Blatt, O., Rotem, B.S., Lebendiker, M., Larisch, S., Friedler, A. (2011) Mechanism of the Interaction between the Intrinsically Disordered C-Terminus of the Pro-Apoptotic ARTS Protein and the Bir3 Domain of XIAP PLoS ONE. 6(9): e24655 [PDF]

    (45) Siman, P., Blatt, O., Moyal, T., Danieli, T., Lebendiker, M., Lashuel, H.A., Friedler, A.*, and Brick, A*. (2011) Chemical Synthesis and Expression of the HIV-1 Rev Protein. ChemBiochem. 12(7): 1097-1104 [Pubmed] [PDF]

    (44) Flashner, E., Raviv, U., and Friedler, A. (2011) The effect of tachykinin neuropeptides on amyloid beta aggregation. Biochem Biophys Res Commun. 407(1):13-7 [PubMed] [PDF]

    (43) Katz, C., Levy-Beladev, L., Rotem-Bamberger, S., Rito, T., Rudiger, S., and Friedler, A. (2010) Studying Protein-Protein Interactions Using Peptide Arrays. Chemical Society Reviews. 40: 2131-2145 [PubMed] [PDF]

    (42) Sukenik, S., Politi, R., Ziserman, L., Danino, D., Friedler, A., and Harries, D. (2010) Crowding Alone Cannot Account for Cosolute Effect on Amyloid Aggregation. PLoS ONE. 6(1): e15608 [PubMed] [PDF]

    (41) Noutsou, M., Duarte, A. M., Anvarian, Z., Didenko, T., Minde, D. P., Kuper, I., de Ridder, I., Oikonomou, C., Friedler, A., Boelens, R., Rudiger, S. G., and Maurice, M. M. (2010) Critical Scaffolding Regions of the Tumor Suppressor Axin1 Are Natively Unfolded. J Mol Biol In Press [PubMed] [PDF]

    (40) Levin, A., Benyamini, H., Hayouka, Z., Friedler, A., and Loyter, A. (2010) Peptides that bind the HIV-1 integrase and modulate its enzymatic activity: Kinetic studies and mode of action. FEBS J. In Press [PubMed] [PDF]

    (39) Friedler, A. (2010) From peptides to proteins: lessons from my years at the Centre for Protein Engineering. Protein Eng Des Sel [PubMed] [PDF]

    (38) Hayouka, Z., Hurevich, M., Levin, A., Benyamini, H., Iosub, A., Maes, M., Shalev, D. E., Loyter, A., Gilon, C., and Friedler, A. (2010) Cyclic peptide inhibitors of HIV-1 integrase derived from the LEDGF/p75 protein. Bioorg Med Chem 18, 8388-95 [PubMed] [PDF]

    (37) Hayouka, Z., Levin, A., Loyter, A., and Friedler, A. (2010) Peptide inhibitors of the HIV-1 integrase protein. Bulletin of the Israel Chemical Society 25, 20-28 [PDF]

    (36) Levy-Beladev, L., Levdansky, L., Gaberman, E., Friedler, A., and Gorodetsky, R. (2010) A family of cell-adhering peptides homologous to fibrinogen C-termini. Biochem Biophys Res Commun 401, 124-30 [PubMed] [PDF]

    (35) Levin, A., Hayouka, Z., Friedler, A., and Loyter, A. (2010) Transportin 3 and importin alpha are required for effective nuclear import of HIV-1 integrase in virus-infected cells. Nucleus 1, 422-431 [abstract] [PDF]

    (34) Levin, A., Hayouka, Z., Friedler, A., and Loyter, A. (2010) Nucleocytoplasmic shuttling of HIV-1 integrase is controlled by the viral Rev protein. Nucleus 1, 190-201 [abstract] [PDF]

    (33) Levin, A., Hayouka, Z., Friedler, A., and Loyter, A. (2010) Specific eradication of HIV-1 from infected cultured cells. AIDS Res Ther 7, 31 [PubMed] [PDF]

    (32) Poyurovsky, M. V., Katz, C., Laptenko, O., Beckerman, R., Lokshin, M., Ahn, J., Byeon, I. J., Gabizon, R., Mattia, M., Zupnick, A., Brown, L. M., Friedler, A., and Prives, C. (2010) The C terminus of p53 binds the N-terminal domain of MDM2. Nat Struct Mol Biol 17, 982-9 [PubMed] [PDF]

    (31) Canello, T., Frid, K., Gabizon, R., Lisa, S., Friedler, A., Moskovitz, J., Gasset, M., and Gabizon, R. (2010) Oxidation of Helix-3 methionines precedes the formation of PK resistant PrP. PLoS Pathog 6, e1000977 [PubMed] [PDF]

    (30) Levin, A., Hayouka, Z., Friedler, A., and Loyter, A. (2010) Peptides derived from the HIV-1 integrase promote HIV-1 infection and multi-integration of viral cDNA in LEDGF/p75-knockdown cells. Virol J 7, 177 [PubMed] [PDF]

    (29) Benyamini, H., and Friedler, A. (2010) The ASPP interaction network: electrostatic differentiation between pro- and anti-apoptotic proteins. J Mol Recognit

    [PubMed] [PDF]

    (28) Benyamini, H., and Friedler, A. (2010) Using peptides to study protein-protein interactions. Future Med Chem 2, 989-1003 [abstract] [PDF]

    (27) Garty, S., Kimelman-Bleich, N., Hayouka, Z., Cohn, D., Friedler, A., Pelled, G., and Gazit, D. (2010) Peptide-modified smart hydrogels and genetically engineered stem cells for skeletal tissue engineering. Biomacromolecules 11, 1516-26 [PubMed]

    (26) Reingewertz, T. H., Shalev, D. E., and Friedler, A. (2010) Structural disorder in the HIV-1 Vif protein and interaction-dependent gain of structure. Protein Pept Lett 17, 988-98 [PubMed]

    (25) Levin, A., Hayouka, Z., Helfer, M., Brack-Werner, R., Friedler, A., and Loyter, A. (2010) Stimulation of the HIV-1 integrase enzymatic activity and cDNA integration by a peptide derived from the integrase protein. Biopolymers 93, 740-51 [PubMed]

    (24) Hayouka, Z., Levin, A., Maes, M., Hadas, E., Shalev, D. E., Volsky, D. J., Loyter, A., and Friedler, A. (2010) Mechanism of action of the HIV-1 integrase inhibitory peptide LEDGF 361-370. Biochem Biophys Res Commun 394, 260-5 [PubMed] [PDF]

    (23) Levin, A., Hayouka, Z., Friedler, A., Brack-Werner, R., Volsky, D. J., and Loyter, A. (2010) A novel role for the viral Rev protein in promoting resistance to superinfection by human immunodeficiency virus type 1. J Gen Virol 91, 1503-13 [PubMed] [PDF]

    (22) Ronen, D., Rosenberg, M. M., Shalev, D. E., Rosenberg, M., Rotem, S., Friedler, A., and Ravid, S. (2010) The positively charged region of the myosin IIC non-helical tailpiece promotes filament assembly. J Biol Chem 285, 7079-86

    [PubMed] [PDF]

    (21) Levin, A., Hayouka, Z., Friedler, A., and Loyter, A. (2010) Over-expression of the HIV-1 Rev promotes death of nondividing eukaryotic cells. Virus Genes 40, 341-6 [PubMed] [PDF]

    (20) Levin, A., Rosenbluh, J., Hayouka, Z., Friedler, A., and Loyter, A. (2010) Integration of HIV-1 DNA is regulated by interplay between viral rev and cellular LEDGF/p75 proteins. Mol Med 16, 34-44 [PubMed] [PDF]

    (19) Levin, A., Hayouka, Z., Brack-Werner, R., Volsky, D. J., Friedler, A., and Loyter, A. (2009) Novel regulation of HIV-1 replication and pathogenicity: Rev inhibition of integration. Protein Eng Des Sel 22, 753-63 [PubMed] [PDF]

    (18) Maes, M., Levin, A., Hayouka, Z., Shalev, D. E., Loyter, A., and Friedler, A. (2009) Peptide inhibitors of HIV-1 integrase: from mechanistic studies to improved lead compounds. Bioorg Med Chem 17, 7635-42 [PubMed]

    (17) Benyamini, H., Leonov, H., Rotem, S., Katz, C., Arkin, I. T., and Friedler, A. (2009) A model for the interaction between NF-kappa-B and ASPP2 suggests an I-kappa-B-like binding mechanism. Proteins 77, 602-11 [PubMed] [PDF]

    (16) Reingewertz, T. H., Benyamini, H., Lebendiker, M., Shalev, D. E., and Friedler, A. (2009) The C-terminal domain of the HIV-1 Vif protein is natively unfolded in its unbound state. Protein Eng Des Sel 22, 281-7 [PubMed] [PDF]

    (15) Levin, A., Hayouka, Z., Helfer, M., Brack-Werner, R., Friedler, A., and Loyter, A. (2009) Peptides derived from HIV-1 integrase that bind Rev stimulate viral genome integration. PLoS One 4, e4155 [PubMed] [PDF]

    (14) Qvit, N., Hatzubai, A., Shalev, D. E., Friedler, A., Ben-Neriah, Y., and Gilon, C. (2009) Design and synthesis of backbone cyclic phosphorylated peptides: The IkappaB model. Biopolymers 91, 157-68 [PubMed]

    (13) Katz, C., Benyamini, H., Rotem, S., Lebendiker, M., Danieli, T., Iosub, A., Refaely, H., Dines, M., Bronner, V., Bravman, T., Shalev, D. E., Rudiger, S., and Friedler, A. (2008) Molecular basis of the interaction between the antiapoptotic Bcl-2 family proteins and the proapoptotic protein ASPP2. Proc Natl Acad Sci U S A 105, 12277-82 [PubMed] [PDF]

    (12) Rotem, S., Katz, C., Benyamini, H., Lebendiker, M., Veprintsev, D., Rudiger, S., Danieli, T., and Friedler, A. (2008) The structure and interactions of the proline-rich domain of ASPP2. J Biol Chem 283, 18990-9 [PubMed] [PDF]

    (11) Qvit, N., Reuveni, H., Gazal, S., Zundelevich, A., Blum, G., Niv, M. Y., Feldstein, A., Meushar, S., Shalev, D. E., Friedler, A., and Gilon, C. (2008) Synthesis of a novel macrocyclic library: discovery of an IGF-1R inhibitor. J Comb Chem 10, 256-66 [PubMed] [PDF]

    (10) Hayouka, Z., Rosenbluh, J., Levin, A., Maes, M., Loyter, A., and Friedler, A. (2008) Peptides derived from HIV-1 Rev inhibit HIV-1 integrase in a shiftide mechanism. Biopolymers 90, 481-7 [PubMed] [PDF]

    (9) Armon-Omer, A., Levin, A., Hayouka, Z., Butz, K., Hoppe-Seyler, F., Loya, S., Hizi, A., Friedler, A., and Loyter, A. (2008) Correlation between shiftide activity and HIV-1 integrase inhibition by a peptide selected from a combinatorial library. J Mol Biol 376, 971-82 [PubMed] [PDF]

    (8) Gabizon, R., Mor, M., Rosenberg, M. M., Britan, L., Hayouka, Z., Kotler, M., Shalev, D. E., and Friedler, A. (2008) Using peptides to study the interaction between the p53 tetramerization domain and HIV-1 Tat. Biopolymers 90, 105-16 [PubMed] [PDF]

    (7) Rotem, S., Katz, C., and Friedler, A. (2007) Insights into the structure and protein-protein interactions of the pro-apoptotic protein ASPP2. Biochem Soc Trans 35, 966-9 [PubMed] [PDF]

    (6) Coster, G., Hayouka, Z., Argaman, L., Strauss, C., Friedler, A., Brandeis, M., and Goldberg, M. (2007) The DNA damage response mediator MDC1 directly interacts with the anaphase-promoting complex/cyclosome. J Biol Chem 282, 32053-64 [PubMed] [PDF]

    (5) Kirshenboim, N., Hayouka, Z., Friedler, A., and Hizi, A. (2007) Expression and characterization of a novel reverse transcriptase of the LTR retrotransposon Tf1. Virology 366, 263-76 [PubMed] [PDF]

    (4) Hayouka, Z., Rosenbluh, J., Levin, A., Loya, S., Lebendiker, M., Veprintsev, D., Kotler, M., Hizi, A., Loyter, A., and Friedler, A. (2007) Inhibiting HIV-1 integrase by shifting its oligomerization equilibrium. Proc Natl Acad Sci U S A 104, 8316-21 [PubMed] [PDF]

    (3) Rosenbluh, J., Hayouka, Z., Loya, S., Levin, A., Armon-Omer, A., Britan, E., Hizi, A., Kotler, M., Friedler, A., and Loyter, A. (2007) Interaction between HIV-1 Rev and integrase proteins: a basis for the development of anti-HIV peptides. J Biol Chem 282, 15743-53 [PubMed] [PDF]

    (2) Karni-Schmidt, O., Friedler, A., Zupnick, A., McKinney, K., Mattia, M., Beckerman, R., Bouvet, P., Sheetz, M., Fersht, A., and Prives, C. (2007) Energy-dependent nucleolar localization of p53 in vitro requires two discrete regions within the p53 carboxyl terminus. Oncogene 26, 3878-91 [PubMed] [PDF]

    (1) Diamant, S., Podoly, E., Friedler, A., Ligumsky, H., Livnah, O., and Soreq, H. (2006) Butyrylcholinesterase attenuates amyloid fibril formation in vitro. Proc Natl Acad Sci U S A 103, 8628-33 [PubMed] [PDF]