(81) Zhuravel R., Amit E., Elbaz S., Rotem D., Chen Y., Friedler A., Yitzchaik S. and Porath D. (2016) Atomic force microscopy characterization of kinase-mediated phosphorylation of a peptide monolayer Sci. Rep. [Link]

    (80) Postel S., Deredge D., Bonsor D. A., Yu X., Diederichs K, Helmsing S., Vromen A., Friedler A., Hust M., Egelman E. H., Beckett D., Wintrode P. L. and Sundberg E. J. (2016) Bacterial flagellar capping proteins adopt diverse oligomeric states eLife [Link]

    (79) Chandra K., Das P., Mamidi S., Hurevich M., Iosub-Amir A., Metanis N., Reches M. and Friedler A. (2016) Covalent Inhibition of HIV-1 Integrase by N-Succinimidyl Peptides ChemMedChem [Link]

    (78) Dwivedi M., Sukenik S., Friedler A. and Padan E. (2016) The Ec-NhaA antiporter switches from antagonistic to synergistic antiport upon a single point mutation Sci. Rep. [Link]

    (77) Amartely H., David A., Shamir M., Lebendiker M., Izraeli S. and Friedler A. (2016) Differential effects of Zinc binding on structured and disordered regions in the multidomain STIL protein Chem. Sci. [Link]

    (76) Iosub-Amir A., Rosmalen M., Mayer G., Lebendiker M., Danieli T. and Friedler A. (2015) Highly homologous proteins exert opposite biological activities by using different interaction interfaces Sci. Rep. [Link]

    (75) Chandra K., Maes M., Friedler A. (2015) Interactions of HIV-1 proteins as targets for developing anti-HIV-1 peptides Future Med. Chem. [PDF]

    (74) Reingewertz T. H., Iosub-Amir A., Bonsor D. A., Mayer G.,Amartely H., Friedler A., Sundberg E. J. (2015) An Intrinsically Disordered Region in the Proapoptotic ASPP2 Protein Binds to the Helicobacter pylori Oncoprotein CagA Biochemistry [Link]

    (73) Amit E., Obena R. P., Wang Y., Zhuravel R., Reyes A., Elbaz S., Rotem D., Porath D., Friedler A., Chen Y. and Yitzchaik S. (2015) Integrating proteomics with electrochemistry for identifying kinase biomarkers Chem. Sci. [Link]

    (72) Snir E., Amit E., Friedler A., Yitzchaik S. (2015) A Highly Sensitive Square Wave Voltammetry Based Biosensor for Kinase Activity Measurements Biopolymers [Link]

    (71) Lebendiker M., Maes M., Friedler A. (2014) A screening methodology for purifying proteins with aggregation problems Methods Mol Biol. [Link]

    (70) Amartely H., Iosub-Amir A., Friedler A. (2014) Identifying Protein-protein Interaction Sites Using Peptide Arrays JoVE. [Link]

    (69) Maes M., Amit E., Danieli T., Lebendiker M., Loyter A., Friedler A. (2014) The disordered region of Arabidopsis VIP1 binds the Agrobacterium VirE2 protein outside its DNA-binding site Protein Eng Des Sel. [PDF]

    (68) Faust O., Bigman L., Friedler A. (2014) A role for a disordered domain in regulating protein oligomerization and stability Chem. Comm. [Link]

    (67) Iosub-Amir A. and Friedler A. (2014) Protein-protein interactions of ASPP2: an emerging therapeutic target Med. Chem. Comm. [Link]

    (66) Zeytuni N., Uebe R., Maes M., Davidov G., Baram M., Raschdorf O., Friedler A., Miller Y., Schüler D., Zarivach R. (2014) Bacterial magnetosome biomineralization--a novel platform to study molecular mechanisms of human CDF-related Type-II diabetes PLoS One 9(5): e97154 [PDF]

    (65) Chandra K., Kanchan RT., Shalev DE, Loyter A., Gilon C., Gerber RB, Friedler A. (2014) A Tandem In Situ Peptide Cyclization through Trifluoroacetic Acid Cleavage Angewandte Chemie International Edition [PDF]

    (64) Tamir S., Rotem-Bamberger S., Katz C., Morcos F., Hailey KL, Zuris JA, Wang C., Conlan AR, Lipper CH, Paddock ML, Mittler R, Onuchic JN, Jennings PA, Friedler A., Nechushtai R. (2014) Integrated strategy reveals the protein interface between cancer targets Bcl-2 and NAF-1 PNAS 111(14): 5177-5182 [PDF]

    (63) Zeytuni N., Uebe R., Maes M., Davidov G., Baram M., Raschdorf O., Nadav-Tsubery M., Kolusheva S., Bitton R., Goobes G., Friedler A., Miller Y., Schüler D., Zarivach R. (2014) Cation Diffusion Facilitators Transport Initiation and Regulation Is Mediated by Cation Induced Conformational Changes of the Cytoplasmic Domain PLoS ONE 9(3): e92141 [PDF]

    (62) Gabizon R. and Friedler A.(2014) Allosteric Modulation of protein oligomerization: an emerging approach to drug design Fron. Chem. 2:9 [PDF]

    (61) Chandra K., Roy TK, Naoum JN, Gilon C., Gerber RB and Friedler A. (2014) A highly efficient in situ N-acetylation approach for solid phase synthesis Org. Biomol. Chem. 12, 1879-1884 [PDF]

    (60) Shahar OD, Gabizon R., Feine O., Alhadeff R., Ganoth A., et al. (2013) Acetylation of Lysine 382 and Phosphorylation of Serine 392 in p53 Modulate the Interaction between p53 and MDC1 In Vitro. PLoS ONE 8(10): e78472 [PDF]

    (59) Sukenik S., Harries D., Friedler A. (2013) Biophysical Chemistry. In: Reedijk, J. (Ed.) Elsevier Reference Module in Chemistry, Molecular Sciences and Chemical Engineering. In press.

    (58) Bonsor D.A., Weiss E., Iosub-Amir A., Reingewertz T. H., Chen T.W., Haas R., Friedler A., Fischer W., Sundberg E.J.(2013) Characterization of the translocation-competent complex between the Helicobacter pylori oncogenic protein CagA and the accessory protein CagF JBC in press [PDF]

    (57) Amartely H.,David A.,Lebendiker M., Benyamini H., Izraeli S., Friedler A.(2013) The STIL protein contains intrinsically disordered regions that mediate its protein-protein interactions Chem. Comm. 50, 5245-5247 [PDF]

    (56) Reingewertz-Haviv T., Britan-Rosich E., Rotem-Bamberger S., Viard M., Jacobs A., Miller A., Youn Lee J., Hwang J., Blumenthal R., Kotler M., Friedler A.(2013) Mapping the Vif-A3G interaction using peptide arrays: a basis for anti-HIV lead peptides Bioorganic & Medicinal Chemistry in press [PDF]

    (55) Guy S., Rotem D., Hayouka Z., Gabizon R., Zemel L., Loyter A., Porath D. and Friedler A. (2013) Monitoring the HIV-1 Integrase Enzymatic Activity Using Atomic Force Microscope in a 2LTR system ChemComm in press [PDF]

    (54) Rosenberg M., Ronen D., Lahav N., Nazirov E., Ravid S., and Friedler A. (2013) High resolution characterization of myosin IIC tailpiece and its effect on filament assembly JBC in press [PDF]

    (53) Gabizon R, Faust O, Benyamini H, Nir S, Loyter A, Friedler A. (2013) Structure-activity relationship studies using peptide arrays: the example of HIV-1 Rev-integrase interaction MedChemComm 4: 252-259 [PubMed] [PDF]

    (52) Maes M, Rimon A, Kozachkov-Magrisso L, Friedler A, Padan E. (2012) Revealing the Ligand Binding Site of NhaA Na+/H+ Antiporter and its pH Dependence J Biol Chem in press [PubMed] [PDF]

    (51) Maes M, Loyter A, Friedler A. (2012) Peptides that inhibit HIV-1 integrase by blocking its protein-protein interactions FEBS Journal 279(16): 2795-2809 [PubMed] [PDF]

    (50) Gabizon R, Brandt T, Sukenik S, Lahav N, Lebendiker M, Shalev DE, Veprintsev D, Friedler A. (2012) Specific Recognition of p53 Tetramers by Peptides Derived from p53 Interacting Proteins PLoS ONE 7(5): e38060 [PubMed] [PDF]

    (49) Natalia Edison, Tali-Haviv Reingewertz, Yossi Gottfried, Tali Lev, Dotan Zuri, Inbal Maniv, Marie-Jeanne Carp, Gil Shalev, Assaf Friedler, and Sarit Larisch. (2012) Peptides Mimicking the Unique ARTS-XIAP Binding Site Promote Apoptotic Cell Death in Cultured Cancer Cells Clin Cancer Res. 18(9):2569-78 [PubMed] [PDF]

    (48) Hayouka Z, Levin A, Hurevich M, Shalev DE, Loyter A, Gilon C, Friedler A. (2012) A comparative study of backbone versus side chain peptide cyclization: Application for HIV-1 integrase inhibitors. J Biol Chem. 287(18):15016-23 [PubMed] [PDF]

    (47) Katz, C., Zaltsman-Amir, Y., Mostizky, Y., Kollet, N., Gross, A. and Friedler, A. (2012) Molecular Basis of the Interaction between the pro apoptotic tBID protein and mitochondrial carrier homologue 2 (MTCH2): Key Players in the Mitochondrial Death Pathway JBC. 287: 15016-15023. [Pubmed] [PDF]

    (46) Reingewertz, T.H., Shalev, D.E., Sukenik, S., Blatt, O., Rotem, B.S., Lebendiker, M., Larisch, S., Friedler, A. (2011) Mechanism of the Interaction between the Intrinsically Disordered C-Terminus of the Pro-Apoptotic ARTS Protein and the Bir3 Domain of XIAP PLoS ONE. 6(9): e24655 [PDF]

    (45) Siman, P., Blatt, O., Moyal, T., Danieli, T., Lebendiker, M., Lashuel, H.A., Friedler, A.*, and Brick, A*. (2011) Chemical Synthesis and Expression of the HIV-1 Rev Protein. ChemBiochem. 12(7): 1097-1104 [Pubmed] [PDF]

    (44) Flashner, E., Raviv, U., and Friedler, A. (2011) The effect of tachykinin neuropeptides on amyloid beta aggregation. Biochem Biophys Res Commun. 407(1):13-7 [PubMed] [PDF]

    (43) Katz, C., Levy-Beladev, L., Rotem-Bamberger, S., Rito, T., Rudiger, S., and Friedler, A. (2010) Studying Protein-Protein Interactions Using Peptide Arrays. Chemical Society Reviews. 40: 2131-2145 [PubMed] [PDF]

    (42) Sukenik, S., Politi, R., Ziserman, L., Danino, D., Friedler, A., and Harries, D. (2010) Crowding Alone Cannot Account for Cosolute Effect on Amyloid Aggregation. PLoS ONE. 6(1): e15608 [PubMed] [PDF]

    (41) Noutsou, M., Duarte, A. M., Anvarian, Z., Didenko, T., Minde, D. P., Kuper, I., de Ridder, I., Oikonomou, C., Friedler, A., Boelens, R., Rudiger, S. G., and Maurice, M. M. (2010) Critical Scaffolding Regions of the Tumor Suppressor Axin1 Are Natively Unfolded. J Mol Biol In Press [PubMed] [PDF]

    (40) Levin, A., Benyamini, H., Hayouka, Z., Friedler, A., and Loyter, A. (2010) Peptides that bind the HIV-1 integrase and modulate its enzymatic activity: Kinetic studies and mode of action. FEBS J. In Press [PubMed] [PDF]

    (39) Friedler, A. (2010) From peptides to proteins: lessons from my years at the Centre for Protein Engineering. Protein Eng Des Sel [PubMed] [PDF]

    (38) Hayouka, Z., Hurevich, M., Levin, A., Benyamini, H., Iosub, A., Maes, M., Shalev, D. E., Loyter, A., Gilon, C., and Friedler, A. (2010) Cyclic peptide inhibitors of HIV-1 integrase derived from the LEDGF/p75 protein. Bioorg Med Chem 18, 8388-95 [PubMed] [PDF]

    (37) Hayouka, Z., Levin, A., Loyter, A., and Friedler, A. (2010) Peptide inhibitors of the HIV-1 integrase protein. Bulletin of the Israel Chemical Society 25, 20-28 [PDF]

    (36) Levy-Beladev, L., Levdansky, L., Gaberman, E., Friedler, A., and Gorodetsky, R. (2010) A family of cell-adhering peptides homologous to fibrinogen C-termini. Biochem Biophys Res Commun 401, 124-30 [PubMed] [PDF]

    (35) Levin, A., Hayouka, Z., Friedler, A., and Loyter, A. (2010) Transportin 3 and importin alpha are required for effective nuclear import of HIV-1 integrase in virus-infected cells. Nucleus 1, 422-431 [abstract] [PDF]

    (34) Levin, A., Hayouka, Z., Friedler, A., and Loyter, A. (2010) Nucleocytoplasmic shuttling of HIV-1 integrase is controlled by the viral Rev protein. Nucleus 1, 190-201 [abstract] [PDF]

    (33) Levin, A., Hayouka, Z., Friedler, A., and Loyter, A. (2010) Specific eradication of HIV-1 from infected cultured cells. AIDS Res Ther 7, 31 [PubMed] [PDF]

    (32) Poyurovsky, M. V., Katz, C., Laptenko, O., Beckerman, R., Lokshin, M., Ahn, J., Byeon, I. J., Gabizon, R., Mattia, M., Zupnick, A., Brown, L. M., Friedler, A., and Prives, C. (2010) The C terminus of p53 binds the N-terminal domain of MDM2. Nat Struct Mol Biol 17, 982-9 [PubMed] [PDF]

    (31) Canello, T., Frid, K., Gabizon, R., Lisa, S., Friedler, A., Moskovitz, J., Gasset, M., and Gabizon, R. (2010) Oxidation of Helix-3 methionines precedes the formation of PK resistant PrP. PLoS Pathog 6, e1000977 [PubMed] [PDF]

    (30) Levin, A., Hayouka, Z., Friedler, A., and Loyter, A. (2010) Peptides derived from the HIV-1 integrase promote HIV-1 infection and multi-integration of viral cDNA in LEDGF/p75-knockdown cells. Virol J 7, 177 [PubMed] [PDF]

    (29) Benyamini, H., and Friedler, A. (2010) The ASPP interaction network: electrostatic differentiation between pro- and anti-apoptotic proteins. J Mol Recognit

    [PubMed] [PDF]

    (28) Benyamini, H., and Friedler, A. (2010) Using peptides to study protein-protein interactions. Future Med Chem 2, 989-1003 [abstract] [PDF]

    (27) Garty, S., Kimelman-Bleich, N., Hayouka, Z., Cohn, D., Friedler, A., Pelled, G., and Gazit, D. (2010) Peptide-modified smart hydrogels and genetically engineered stem cells for skeletal tissue engineering. Biomacromolecules 11, 1516-26 [PubMed]

    (26) Reingewertz, T. H., Shalev, D. E., and Friedler, A. (2010) Structural disorder in the HIV-1 Vif protein and interaction-dependent gain of structure. Protein Pept Lett 17, 988-98 [PubMed]

    (25) Levin, A., Hayouka, Z., Helfer, M., Brack-Werner, R., Friedler, A., and Loyter, A. (2010) Stimulation of the HIV-1 integrase enzymatic activity and cDNA integration by a peptide derived from the integrase protein. Biopolymers 93, 740-51 [PubMed]

    (24) Hayouka, Z., Levin, A., Maes, M., Hadas, E., Shalev, D. E., Volsky, D. J., Loyter, A., and Friedler, A. (2010) Mechanism of action of the HIV-1 integrase inhibitory peptide LEDGF 361-370. Biochem Biophys Res Commun 394, 260-5 [PubMed] [PDF]

    (23) Levin, A., Hayouka, Z., Friedler, A., Brack-Werner, R., Volsky, D. J., and Loyter, A. (2010) A novel role for the viral Rev protein in promoting resistance to superinfection by human immunodeficiency virus type 1. J Gen Virol 91, 1503-13 [PubMed] [PDF]

    (22) Ronen, D., Rosenberg, M. M., Shalev, D. E., Rosenberg, M., Rotem, S., Friedler, A., and Ravid, S. (2010) The positively charged region of the myosin IIC non-helical tailpiece promotes filament assembly. J Biol Chem 285, 7079-86

    [PubMed] [PDF]

    (21) Levin, A., Hayouka, Z., Friedler, A., and Loyter, A. (2010) Over-expression of the HIV-1 Rev promotes death of nondividing eukaryotic cells. Virus Genes 40, 341-6 [PubMed] [PDF]

    (20) Levin, A., Rosenbluh, J., Hayouka, Z., Friedler, A., and Loyter, A. (2010) Integration of HIV-1 DNA is regulated by interplay between viral rev and cellular LEDGF/p75 proteins. Mol Med 16, 34-44 [PubMed] [PDF]

    (19) Levin, A., Hayouka, Z., Brack-Werner, R., Volsky, D. J., Friedler, A., and Loyter, A. (2009) Novel regulation of HIV-1 replication and pathogenicity: Rev inhibition of integration. Protein Eng Des Sel 22, 753-63 [PubMed] [PDF]

    (18) Maes, M., Levin, A., Hayouka, Z., Shalev, D. E., Loyter, A., and Friedler, A. (2009) Peptide inhibitors of HIV-1 integrase: from mechanistic studies to improved lead compounds. Bioorg Med Chem 17, 7635-42 [PubMed]

    (17) Benyamini, H., Leonov, H., Rotem, S., Katz, C., Arkin, I. T., and Friedler, A. (2009) A model for the interaction between NF-kappa-B and ASPP2 suggests an I-kappa-B-like binding mechanism. Proteins 77, 602-11 [PubMed] [PDF]

    (16) Reingewertz, T. H., Benyamini, H., Lebendiker, M., Shalev, D. E., and Friedler, A. (2009) The C-terminal domain of the HIV-1 Vif protein is natively unfolded in its unbound state. Protein Eng Des Sel 22, 281-7 [PubMed] [PDF]

    (15) Levin, A., Hayouka, Z., Helfer, M., Brack-Werner, R., Friedler, A., and Loyter, A. (2009) Peptides derived from HIV-1 integrase that bind Rev stimulate viral genome integration. PLoS One 4, e4155 [PubMed] [PDF]

    (14) Qvit, N., Hatzubai, A., Shalev, D. E., Friedler, A., Ben-Neriah, Y., and Gilon, C. (2009) Design and synthesis of backbone cyclic phosphorylated peptides: The IkappaB model. Biopolymers 91, 157-68 [PubMed]

    (13) Katz, C., Benyamini, H., Rotem, S., Lebendiker, M., Danieli, T., Iosub, A., Refaely, H., Dines, M., Bronner, V., Bravman, T., Shalev, D. E., Rudiger, S., and Friedler, A. (2008) Molecular basis of the interaction between the antiapoptotic Bcl-2 family proteins and the proapoptotic protein ASPP2. Proc Natl Acad Sci U S A 105, 12277-82 [PubMed] [PDF]

    (12) Rotem, S., Katz, C., Benyamini, H., Lebendiker, M., Veprintsev, D., Rudiger, S., Danieli, T., and Friedler, A. (2008) The structure and interactions of the proline-rich domain of ASPP2. J Biol Chem 283, 18990-9 [PubMed] [PDF]

    (11) Qvit, N., Reuveni, H., Gazal, S., Zundelevich, A., Blum, G., Niv, M. Y., Feldstein, A., Meushar, S., Shalev, D. E., Friedler, A., and Gilon, C. (2008) Synthesis of a novel macrocyclic library: discovery of an IGF-1R inhibitor. J Comb Chem 10, 256-66 [PubMed] [PDF]

    (10) Hayouka, Z., Rosenbluh, J., Levin, A., Maes, M., Loyter, A., and Friedler, A. (2008) Peptides derived from HIV-1 Rev inhibit HIV-1 integrase in a shiftide mechanism. Biopolymers 90, 481-7 [PubMed] [PDF]

    (9) Armon-Omer, A., Levin, A., Hayouka, Z., Butz, K., Hoppe-Seyler, F., Loya, S., Hizi, A., Friedler, A., and Loyter, A. (2008) Correlation between shiftide activity and HIV-1 integrase inhibition by a peptide selected from a combinatorial library. J Mol Biol 376, 971-82 [PubMed] [PDF]

    (8) Gabizon, R., Mor, M., Rosenberg, M. M., Britan, L., Hayouka, Z., Kotler, M., Shalev, D. E., and Friedler, A. (2008) Using peptides to study the interaction between the p53 tetramerization domain and HIV-1 Tat. Biopolymers 90, 105-16 [PubMed] [PDF]

    (7) Rotem, S., Katz, C., and Friedler, A. (2007) Insights into the structure and protein-protein interactions of the pro-apoptotic protein ASPP2. Biochem Soc Trans 35, 966-9 [PubMed] [PDF]

    (6) Coster, G., Hayouka, Z., Argaman, L., Strauss, C., Friedler, A., Brandeis, M., and Goldberg, M. (2007) The DNA damage response mediator MDC1 directly interacts with the anaphase-promoting complex/cyclosome. J Biol Chem 282, 32053-64 [PubMed] [PDF]

    (5) Kirshenboim, N., Hayouka, Z., Friedler, A., and Hizi, A. (2007) Expression and characterization of a novel reverse transcriptase of the LTR retrotransposon Tf1. Virology 366, 263-76 [PubMed] [PDF]

    (4) Hayouka, Z., Rosenbluh, J., Levin, A., Loya, S., Lebendiker, M., Veprintsev, D., Kotler, M., Hizi, A., Loyter, A., and Friedler, A. (2007) Inhibiting HIV-1 integrase by shifting its oligomerization equilibrium. Proc Natl Acad Sci U S A 104, 8316-21 [PubMed] [PDF]

    (3) Rosenbluh, J., Hayouka, Z., Loya, S., Levin, A., Armon-Omer, A., Britan, E., Hizi, A., Kotler, M., Friedler, A., and Loyter, A. (2007) Interaction between HIV-1 Rev and integrase proteins: a basis for the development of anti-HIV peptides. J Biol Chem 282, 15743-53 [PubMed] [PDF]

    (2) Karni-Schmidt, O., Friedler, A., Zupnick, A., McKinney, K., Mattia, M., Beckerman, R., Bouvet, P., Sheetz, M., Fersht, A., and Prives, C. (2007) Energy-dependent nucleolar localization of p53 in vitro requires two discrete regions within the p53 carboxyl terminus. Oncogene 26, 3878-91 [PubMed] [PDF]

    (1) Diamant, S., Podoly, E., Friedler, A., Ligumsky, H., Livnah, O., and Soreq, H. (2006) Butyrylcholinesterase attenuates amyloid fibril formation in vitro. Proc Natl Acad Sci U S A 103, 8628-33 [PubMed] [PDF]