Research Activities
 
Inorganic chemistry
Organic synthesis   Bioinorganic Chemistry: On the Interface of Coordination Chemistry and Biology
   

Design of novel chelating ligands for transition metal complexes
Design of inorganic compounds with biological and medicinal applications;
Study of their reactivity and mechanism of action
Development of synthetic model compounds of metalloproteins having variable chemical and medicinal applications
Development of small molecule and polymer bound metal compounds and
study of their potential therapeutic value
 
  Ti(IV) Complexes for Biological Applications In vitro measurements
   
  In this project we synthesize Ti(IV) complexes of various ligands
and study their properties and reactivity with emphasis on elucidating their hydrolytic behavior. We have developed several compounds exhibiting varying degrees of cytotoxicity, with interesting effects of steric bulk and particular ligand type, and obvious correlation to their hydrolytic behavior. We are currently focusing on elucidating the nature of the active species and elucidating various mechanistic aspects of the cytotoxic activity.
 
Redox potential measurements   Copper(I) Complexes as models for metallochaperones active site
   
  In this project we synthesize complexes of copper(I) with thiolato ligands
to model the binding site in copper metallochaperone proteins. In the natural systems, copper binding is achieved through two cysteine residues. We employ simple thiolato ligands as well as peptides
featuring a similar sequence to that of the natural system. We study
various aspects of their properties and reactivity, including binding modes, redox potential, interaction with biologically relevant oxygen-based species, etc.
Stopped-flow techniques
 
 
       
   
   
   
   
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