List of Publications
 




* Michal S. Shoshan, Yonat Lehman, Wojciech Goch, Wojciech Bal, Edit Y. Tshuva and Norman Metanis, Selenocysteine Containing Analogues of Atx1-based Peptides Protect Cells from Copper Ion Toxicity. Org. Biomol. Chem. 14, 6979 (2016)




* Michal S. Shoshan and Edit Y. Tshuva, Effective Inhibitors of ROS Cellular Production by MXCXXC-Type Peptides: Potential Therapeutic Applications in Copper Homeostasis Disorders. Chem. Eur. J. 22, 9077 (2016)




* Gilad Nahari, Lilia Reytman, Laure Vendier, Edit Y. Tshuva, and Christian Lorber. Cytotoxic Vanadium Complexes of Branched [ONNO]-Type Diamine Bis(Phenolato) Ligands. Eur. J. Inorg. Chem. DOI: 10.1002/ejic.201601276 (2016)




* Avia Tzubery and Edit Y. Tshuva. Cytotoxic Titanium(IV) Complexes of Salalene-Based Ligands. Eur. J. Inorg. Chem. DOI: 10.1002/ejic.201601200 (2016)




* Sigalit Meker, Ori Braitbard, Matthew D. Hall, Jacob Hochman, and Edit Y. Tshuva. Specific Design of Titanium(IV) Phenolato Chelates Yields Stable and Accessible , Effective and Selective Anticancer Agents. Chem. Eur. J. 22, 9986 (2016)




* Maya Miller, Ori Braitbard, Jacob Hochman, and Edit Y. Tshuva, Insights into the Molecular Mechanism of Action of Salan Titanium(IV) Complex with In vitro and In vivo Anticancer Activity. J. Inorg. Biochem. 163, 250 (2016) 




* Michal S. Shoshan, Noa Dekel, Wojciech Goch, Deborah E. Shalev, Tsafi Danieli, Mario Lebendiker, Wojciech Bal, and Edit Y. Tshuva, Unbound Position II in MXCXXC Metallochaperone Model Peptides Impacts Metal Binding Mode and Reactivity: Distinct Similarities to Whole Proteins. J. Inorg. Biochem. 159, 29 (2016)




* Lilia Reytman, Ori Braitbard, Jacob Hochman, and Edit Y. Tshuva, Highly Effective and Hydrolytically Stable Vanadium(V) Amino Phenolato Antitumor Agents. Inorg. Chem. 55, 610 (2016)




* Sigalit Meker, Kathrin Margulis Goshen, Ori Braitbard, Jacob Hochman, Shlomo Magdassi, and Edit Y. Tshuva. Highly Stable Tetra-Phenolato Titanium(IV) Agent Formulated into Nanoparticles Demonstrates Anti-Tumoral Activity and Selectivity. Molecules 20, 18526 (2015)




* Hagai Glasner, Sigalit Meker, and Edit Y. Tshuva. Cationic Phenolato Ti(IV) Complexes of Enhanced Solubility as active and Biologically Accessible Anti-Tumor Compounds. J. Organomet. Chem. 788, 33 (2015)




* Hagai Glasner and Edit Y. Tshuva. Cytotoxic O-Bridged Inert Titanium(IV) Complexes of Phenylenediamine-Bis(phenolato) Ligands. Inorg. Chem. Commun. 31 (2015)




* Nitzan Ganot, Boris Redko, Gary Gellerman, and Edit Y. Tshuva. Anti-Proliferative Activity of the Combination of Salan Titanium(IV) Complexes with other Organic and Inorganic Anticancer DrugsAgainst HT-29 and NCL-H1229 Cells: Synergism with Cisplatin. RSC Advances, 5, 7874 (2015)




* Sigalit Meker, Kathrin Margulis Goshen, Ester Weiss, Ori Braitbard, Jacob Hochman, Shlomo Magdassi, and Edit Y. Tshuva. Anti Proliferative Activity of Nano-Formulated Phenolato Tityanium(IV) Complexes Against Cancer Cells. Chem. Med. Chem. 9, 1294 (2014)




* Hagai Glasner and Edit Y. Tshuva. C1-Symmetrical Titanium(IV) Complexes of Salan Ligands with Differently Substituted Aromatic Rings: Enhanced Cytotoxic Activity. Inorg. Chem. 53, 3170 (2014)




 * Maya Miller and Edit Y. Tshuva. Cytotoxic Titanium(IV) Complexes of Chiral Diaminobis(phenolato) Ligands: Better Combination of Activity and Stability by the Bipyrrolidine Moiety. Eur. J. Inorg. Chem. 1485 (2014)




* Julia Schur, Cesar M. Manna, Edit Y. Tshuva and Ingo Ott. Quantification of the titanium content in metallodrug exposed tumor cells using HR-CS AAS. Metallodrugs 1, 1 (2014)



   * Nitzan Ganot, Sigalit Meker, Lilia Reytman, Avia Tzubery, and Edit Y. Tshuva. Anticancer Metal  Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay. J. Vis. Exp/ 81, e50767 (2013)




* Michal S. Shoshan, Deborah E. Shalev, and Edit Y. Tshuva. Structure and Coordination Determination of Peptide-Metal Complexes Using 1D and 2D 1H NMR. J. Vis. Exp. 82, e50747 (2013).




* Julia Schur, Cesar M. Manna, Anthony Deally, Reinhard W. Köster, Matthias Tacke, Edit Y. Tshuva, and Ingo Ott. A comparative chemical–biological evaluation of titanium(IV) complexes with a salan or cyclopentadienyl ligand. Chem. Commun. 49, 4785 (2013)




* Stuart L. Hancock, Rachel Gati, Mary F. Mahon, Edit Y. Tshuva and Matthew D. Jones. Heteroleptic Titanium(IV) Catecholato/Piperazine Systems and their Anticancer Properties. Dalton Trans. 43, 1380 (2014)




* Michal S. Shoshan, Deborah E. Shalev, and Edit Y. Tshuva. Peptide Models of Cu(I) and Zn(II) Metallochaperones: The Effect of pH on Coordination and Mechanistic Implications. Inorg. Chem. 52, 2993 (2013)




* Sigalit Meker, Katrin Margulis-Goshen, Ester Weiss, Shlomo Magdassi, and Edit Y. Tshuva, High Antitumor Activity of Highly Resistant Salan-Titanium(IV) Complexes in Nanoparticles: An Identified Active Species. Angew. Chim. Int. Ed. 51, 10515 (2012). Selected for Back Cover. Selected as Hot Paper




* Lilia Reytman, Ori Braitbard, and Edit Y. Tshuva, Highly Cytotoxic Vanadium(V) Complexes of Salan Ligands; Insights on the Role of Hydrolysis. Dalton Trans. 41, 5241 (2012)


* Cesar M. Mannam, Ori Braitbard, Esther Weiss, Jacob Hochman and Edit Y. Tshuva, Cytotoxic Salan-Titanium(IV) Complexes: High Activity Towards a Range of Sensitive and Drug Resistant Cell Lines and Mechanistic Insights. ChemMedChem, 7, 703 (2012)


* Avia Tzubery and Edit Y. Tshuva, Cytotoxicity and Hydrolysis of Trans-Ti(IV) Complexes of Salen Ligands: Structure-Activity Relationship Studies. Inorg. Chem. 51, 1796 (2012)


* Hagai Glasner and Edit Y. Tshuva, A Marked Synergistic Effect in Antitumor Activity of Salan Ti(IV) Complexes Bearing Two Differently Substituted Aromatic Rings. J. Am. Chem. Soc. 133, 16812 (2011)


* Dani Peri, Cesar M. Manna, Michal Shavit and Edit Y. Tshuva, TiIV Complexes of Branched Diamine Bis(phenolato) Ligands: Hydrolysis and Cytotoxicity. Eur. J. Inorg. Chem. 4896 (2011)


* Cesar M. Manna, Gad Armony and Edit Y. Tshuva, Unexpected Influence of Stereochemistry on Cytotoxicity of Highly Efficient Ti(IV) Salan Complexes: New mechanistic Insights. Chem. Eur. J. 17, 14094 (2011)


* Sigalit Meker, Cesar M. Manna, Dani Peri and Edit Y. Tshuva, Major impact of N-methylation on cytotoxicity and hydrolysis of salan Ti(IV) complexes: sterics and electronics are intertwined. Dalton Trans. 40, 9802 (2011)


* Cesar M. Manna, Gad Armony and Edit Y. Tshuva, New Insights on the Active Species and Mechanism of Cytotoxicity of Salan-Ti(IV) Complexes: A Stereochemical Study. Inorg Chem. 50, 10284 (2011)


* Michal Shoshan and Edit Y. Tshuva, The MXCXXC Class of Metallochaperone Proteins: Model Studies. Chem. Soc. Rev. 40, 5282 (2011)


* Avia Tzubery and Edit Y. Tshuva, Trans Titanium(IV) Complexes of salen Ligands Exhibit High Antitumor Activity. Inorg. Chem. 50, 7946 (2011)


* Michal Shoshan, Deborah E. Shalev, Wencke Adriaens, Maarten Merkx, Tilman  M. Hackeng, and Edit Y. Tshuva, NMR Characterization of Ci(I)-Bound Peptide Model of Copper Metallochaperones: Insights on the Role of Methionine. Chem. Commun. 47, 6407 (2011)


* Dani Peri, Sigalit Meker, Cesar M. Manna and Edit Y. Tshuva, Different Ortho and Para Electronic Effects on Hydrolysis and Cytotoxicity of Diamino Bis(Phenolato) "Salan" Ti(IV) Complexes. Inorg. Chem. 50, 1030 (2011)


* Cesar M. Manna and Edit Y. Tshuva, Markedly Different Cytotoxicity of the Two Enantiomers of C2-symmetrical Ti(IV) Phenolato Complexes: Mechanistic Implications. Dalton Trans. 39, 1182 (2010)


* Edit Y. Tshuva and James A. Ashenhurst, Cytotoxic Ti(IV) Complexes: Renaissance. Eur. J. Inorg. Chem. 2193 (2009) COVER


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Edit Y. Tshuva and Dani Peri, Modern Cytotoxic Ti(IV) Complexes; Insights on the Enigmatic Involvement of Hydrolysis, Coord. Chem. Rev. 253, 2098 (2009)


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Dani Peri, Sigalit Meker, Michal Shavit and Edit Y. Tshuva, Synthesis, Characterization, Cytotoxicity, and Hydrolytic Behavior of C2 and C1-Symmetrical Ti(IV) Complexes of Tetradentate Diamine Bis(Phenolato) Ligands: A New Class of Antitumor Agents, Chem. Eur. J. 15, 2403 (2009)


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Cesar  M. Manna and Edit Y. Tshuva, Structural Characterization of Dinuclear Complexes of Rigid Tetradentate Dianionic Diamine Bis(Phenolato) Ligands; Effect of Steric Bulk on Coordination Features, J. Organomet. Chem. 693, 3947 (2008)

  *
Tal Hermon and Edit Y. Tshuva, Synthesis and Conformational Analysis of Constrained Ethylene-Bridged Bis(hydroxylamino-1,3,5-triazine) Compounds as
Tetradentate Ligands; Structure of Rigid Dinuclear Ti(IV) Complex , J. Org. Chem. 73, 5953 (2008)

  * Amir Kohner-Kerten and Edit Y. Tshuva, Preparation and X-ray characterization of two-coordinate Cu(I) complex of aliphatic
thiolato ligand: Effect of steric bulk on coordination features, J. Organomet. Chem. 693, 2065 (2008)

  * Michal Shavit and Edit Y. Tshuva, Preparation and X-Ray Structures of Ti(IV) Complexes of Bis(carboxylato) Ligands; Formation of Mono-, Di-, Tetra- and Hexanuclear Complexes With or Without OR and μ-O Ligands, Eur. J. Inorg. Chem. 1467 (2008)

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Shiri Zeevi and Edit Y. Tshuva, Synthesis and X-ray Characterization of Mono- and Polynuclear Thiolatocopper(I) Complexes: The Effect of Steric Bulk on Coordination Number and Nuclearity, Eur. J. Inorg. Chem. 5369 (2007)

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Michal Shavit, Dani Peri, Cesar M. Manna, Jacob S. Alexander and Edit Y. Tshuva, Active Cytotoxic Reagents Based on Non-metallocene Non-diketonato Well-Defined C2-Symmetrical Titanium Complexes of Tetradentate Bis(phenolato) Ligands, J. Am. Chem. Soc. 129, 12098 (2007)

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Michal Shavit, Dani Peri, Artem Melman and Edit Y. Tshuva, Antitumor reactivity of non-metallocene titanium complexes of oxygen-based ligands: is ligand lability essential? J. Biol. Inorg. Chem. 12, 825 (2007)

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Dani Peri, Jacob S. Alexander, Edit Y. Tshuva and Artem Melman, Distinctive Structural Features of Hydroxyamino-1,3,5-Triazine Ligands Leading to Enhanced Hydrolytic Stability of their Titanium Complexes, Dalton Trans, 4169 (2006)

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Stanislav Groysman, Edit Y. Tshuva, Israel Goldberg, Moshe Kol, Zeev Goldschmidt and Michael Shuster, Diverse Structure-Activity Trends in Amine Bis(phenolate) Titanium Polymerization Catalysts, Organometallics, 23, 5291 (2004)

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Rayane F. Moreira, Edit Y. Tshuva and Stephen J. Lippard, Catalytic Oxidative Ring Opening of THF Promoted by a Carboxylate-Bridged Diiron(II) Complex, Triarylphosphines, and Dioxygen, Inorg. Chem., 43, 4427 (2004)

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Edit Y. Tshuva and Stephen J. Lippard, Synthetic Models for Non-Heme Carboxylate-Bridged Diiron Metalloproteins: Strategies and Tactics, Chem. Rev., 104, 987 (2004)

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Moshe Kol, Edit Y. Tshuva and Zeev Goldschmidt, Complexes of Amine Phenolate Ligands as Catalysts for Polymerization of alpha-Olefins., In Beyond Metallocenes. Next Generation Polymerization Catalysts, ACS Symposium Series No. 857, 62 (2003)

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Moshe Kol, Edit Y. Tshuva and Zeev Goldschmidt, Method for Catalytic Polymerization of Alpha-olefin Monomers Using an Ultra-high Activity Non-Metallocene Precatalyst., U.S. Patent , Patent No.: 6,596,827 B2, (2003)

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Edit Y. Tshuva, Stanislav Groysman, Israel Goldberg, Moshe Kol and Zeev Goldschmidt, [ONXO]-Type Amine Bis(phenolate) Zirconium and Hafnium Complexes as Extremely Reactive 1-hexene Polymerization Catalysts: Unusual Metal Dependent Activity Pattern, Organometallics , 21, 662 (2002)

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Edit Y. Tshuva, Dongwhan Lee, Weiming Bu and Stephen J. Lippard, Catalytic Oxidation by Carboxylate-Bridged Non-Heme Diiron Complex, J. Am. Chem. Soc., 124, 2416 (2002)

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Stanislav Groysman, Edit Y. Tshuva, Dvora Reshef, S. Gendler, Israel Goldberg, Moshe Kol, Zeez Goldschmidt, Michael Shuster and Gershon Lidor , High-Molecular Weight Atactic Polypropylene prepared by Zirconium Complexes of an Amine Bis(phenolate) Ligand, Isr. J. Chem., 42, 373 (2002)

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Moshe Kol and Edit Y. Tshuva, Novel Non-Metallocene Catalysts for the Tactic Polymerization of Alpha-Olefin Monomers, U.S. Patent, Application No 09/705,780, (2002)

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Moshe Kol, Edit Y. Tshuva, Stanislav Groysman, Sharon Segal, Israel Goldberg and Zeev Goldschmidt, Group IV Complexes of Amine Phenolate Ligands as Catalysts for Atactic and Tactic Polymerization, Abstr. Pap. Am. Chem. S., 224: 085, (2002)

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Moshe Kol, Edit Y. Tshuva, Stanislav Groysman, Sharon Segal, Israel Goldberg and Zeev Goldschmidt, Amine Phenolate Catalysts for Polymerization of Alpha-Olefins, Abstr. Pap. Am. Chem. S., 223: 015, (2002)

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Edit Y. Tshuva, Israel Goldberg, Moshe Kol and Zeev Goldschmidt, Zirconium Complexes of Amine Bis(phenolate) Ligands as Catalysts for 1-Hexene Polymerization: Peripheral Structural Parameters Strongly Affect Reactivity, Organometallics , 20, 3017 (2001)

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Edit Y. Tshuva, Israel Goldberg, Moshe Kol and Zeev Goldschmidt, Coordination Chemistry of Amine Bis(Phenolate) Titanium Complexes: Tuning Complex Type and Structure by Ligand Modification, Inorg. Chem., 40, 4263 (2001)

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Edit Y. Tshuva, Natalie Gendeziuk and Moshe. Kol, One-Step Synthesis of Salans and Substituted Salans by Mannich Condensation, Tetrahedron Lett., 42, 6405 (2001)

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Edit Y. Tshuva, Israel Goldberg, Moshe Kol and Zeev Goldschmidt, Living polymerization and block copolymerization of a- olefins by an amine bis(phenolate) titanium catalyst, Chem. Commun., 2120 (2001)

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Moshe Kol, Edit Y. Tshuva and Zeev Goldschmidt, Ultra-High Activity Non-Metallocene Pre-Catalyst and Method for Catalytic Polymerization of Alpha-Olefin Monomers, U.S. Patent , Patent No.: 6,333,423 B1, (2001)

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Edit Y. Tshuva, Israel Goldberg, Moshe Kol and Zeev Goldschmidt, Living Polymerization of 1-Hexene Due to an Extra Donor Arm on a Novel Amine bis(phenolate) Titanium Catalyst, Inorg. Chem. Commun., 3, 610 (2000)

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Edit Y. Tshuva, Israel Goldberg, Moshe Kol, Hana Weitman and Zeev Goldschmidt, Novel Zirconium Complexes of Amine Bis(phenolate) Ligands. Remarkable Reactivity in polymerization of 1-Hexene due to an Extra Donor Arm, Chem. Commun., , 379 (2000)

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Edit Y. Tshuva, Israel Goldberg and Moshe Kol, Isospecific Living Polymerization of 1-Hexene by a Readily Available Non-metallocene C2-Symmetrical Zirconium Catalyst, J. Am. Chem. Soc., 122, 10706 (2000)

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Edit Y. Tshuva, Miriam Versano, Israel Goldberg, Moshe Kol, Hana Weitman and Zeev Goldschmidt, Titanium Complexes of Chelating Dianionic Amine Bis(phenolate) Ligands: an Extra Donor Makes a Big Difference, Inorg. Chem. Commun., 2, 371 (1999)
     
 
 
       
   
   
   
   
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