Research Activities



Research Activities- "Interfacial phenomena in dispersed liquids"

a) Summary
  • Surfactant chemistry

  • Crystallization phenomena and polymorphism of fats, cocoa butter, fatty acids, cholesterol and phytosterols and lipids

  • Liquid dispersed systems - Emulsions, microemulsions, double emulsions, emulsified microemulsions,

  • Novel nanosized self-assembled liquid vehicles (NSSL technology)

  • Novel lyotropic liquid crystals (QL and micellosomes) as solubilization vehicles for improved solubilization capacities of non-soluble bioactives and bioavailability

  • Transdermal and transmembrane competitive transport via nano-vehicles

  • Nutraceuticals and food supplements- structure, mechanisms and bioavailability

  • Regioselectivity and Interfacial Reactions (enzymatic and chemical)

  • Food chemistry with emphasis on fats, oils, fatty acids, lipids

  • Hydrocolloids and proteins as amphiphiles - Extraction, enzymatic modification, hybridization, structure and reactivity.

  • Development of new and advanced analytical tools for studying structural aspects of nanosized systems such as SAXS, SD-NMR, Cryo-TEM, Dielectric Spectroscopy, DSC, rheology, EPR, TDS, etc.

  • Alternative and new synthesis of surfactants and bio amphiphiles

b) The group is organized into subunits with various competences in the areas of:
  • Synthetic organic chemistry of surfactants

  • Physical chemistry, surface and colloid science, emulsion technology, crystallization phenomena, extraction processes

  • Nutraceuticals - extraction, characterization, solubilization and bioavailability of molecules from natural sources with health benefits

  • Drug Delivery vehicles- Nanosized Self-assembled Liquid (NSSL) vehicles

  • Lyotropic Liquid Crystals (LLC) - Formation, structure studies, solubilization and transformations of cubosomes, hexosomes

  • Novel liquid micellar discontinuous phases- the QL phase.

  • Bioavailability of nutraceuticals and drugs

  • Competitive adsorption (cholesterol and phytosterols)
c) More specifically the group is involved in the following activities:
  • Search for new or modified nanosized self-assembled liquid (NSSL) vehicles by controlling geometries, curvatures, interfacial tensions, etc.

  • Solubilize and orient reactants and precursors for making specific and regioselective organic (signature flavoring and aroma molecules) and enzymatic (phospholipids, monoglycerides) products.

  • Using nanodroplets as nano-reactors for crystallization processes yielding new polymorphic crystals (drugs, sweeteners, nutraceuticals).

  • Solubilization of insoluble active molecules (drugs and nutraceuticals) and use the nano-vehicles to transport the guest molecules to food products and via the digestive tracts to the blood stream.

  • Competitive solubilization of bioactives at interfaces of microemulsions.

  • Stabilization (physically or chemically) of sensitive molecules against oxidation in dispersed systems (i.e. lycopene, lutein, tocopherols).

  • Control the release of active molecules from the core of the dispersed system (microemulsion, microcapsule) to the outer continuous interface.

  • Design new emulsifiers and to prepare new products with significant commercial and scientific advantages.

  • Modify proteins and hydrocolloids to form nanosized aggregates.

  • Prepare emulsified microemulsions (modified double emulsions) for improved solubilization and control the release of entrapped matter.

  • Food emulsions and interfacial modifications.

  • Nutraceuticals - solubilization and characterization.

  • Novel double emulsions Emulsified microemulsions (EME).

  • Transdermal transport of drugs and dermal penetration of bioactives.

  • Transmembrane drug delivery of insoluble drugs.

 

 

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